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KMID : 0604520180440040437
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Journal of the Society of Cosmetic Scientists of Korea
2018 Volume.44 No. 4 p.437 ~ p.445
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Development of Novel Sulforaphane Contained-composition to Increase Antioxidant and Whitening Effects
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Lee Ji-Hye
Choi Kang-Hyun
Park Young-Kum
Kim Eung-Gook
Shin Eun-Young
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Abstract
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In this study, we analyzed two components, sulforaphane and PF-3758309 to prove that the mixed composition of them has more effective antioxidant and whitening functions compared to each component. We analyzed the cellular toxicity of each component and also the mixed composition to find the safe concentration level for cell viability. From the single component treatment, we discovered that sulforaphane was safe up to 10 μM, and PF-3758309 up to 100 nM. Combination treatment of 10 μM sulforaphane and 1 nM PF-3758309 did not affect the cell viability. The LPS-stimulated NO generation was significantly reduced by the mixed composition of sulforaphane and PF-3758309. Melanogenesis by α-melanocyte stimulating hormone (α-MSH) was also inhibited by the mixed composition. In order to confirm the possibility as the cosmetic material, we carried out clinical studies for the mixed composition samples. Skin safety evaluation using patch test was judged to be unstimulated, skin whitening effect was increased, and melanin deposition was suppressed by treatment of mixed composition samples. These results provide us with the opportunity for applying it into the development of new functional cosmetics.
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KEYWORD
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sulforaphane, functional cosmetics, antioxidant, whitening, skin
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